Tiki newsletter works well for small volumes.
But for large volumes, as with any web app, sending emails from a server can be a challenge. Risk of being flagged as spammer, high server load/difficult to throttle, limits from your web hosts (ex.: max x emails per hour), etc
A helpful alternative would be something like this:
So my Thunderbird client or desktop newsletter application (ex.: Gammadybe Mailer) should be able to access the TikiWiki database to generate recipient list.
Another approach is to make the Tiki contacts (address book) accessible via the LDAP protocol and thus, email clients can access.
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